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Showing posts from October, 2014

All Work and No Play

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These days, I find myself providing strange and quirky examples to elucidate certain   concepts in  molecular biology  to a classroom of 50 sleep-induced, hungover and relatively withdrawn young minds. "Imagine you want to murder someone.. and you want to do it with a knife. Why a knife? Well, because knives are slow and painful and you can see the fear in your enemy's eyes as life slowly drains away.." (Here I paused, to give theatrics a chance)  "..but then I go and hide all your knives away! You come into the room to face the person you want to kill. But suddenly you can't kill him - or her, not to sound sexist - because I took away the only weapon you ever had!" I paused, to let them try to figure it out a little by themselves before I give away the final conclusion of the elaborate example - "that's what EDTA does. It takes away the cation cofactors that the nuclease needs, in order to cleave the DNA. Get it? Get it?" Sometime